There are no publications at present describing germline CNOT3 deletions or other types of loss-of-function mutations. De Keersmaecker et al identified CNOT3 as a tumor suppressor mutated in 7.9% of adult T-ALLs, and its knockdown caused tumors in a sensitized Drosophila melanogaster model (PMID: 23263491). Richter-Pecha?ska et al. found CNOT3 mutations in pediatric T-ALL relapses (PMID: 28157215).
There are no publications at present describing germline CNOT3 duplications.