ClinGen Dosage Sensitivity Curation Page

WRN

  • Curation Status: Complete

Location Information

Select assembly: (NC_000008.10) (NC_000008.11)
  • Haploinsufficiency score: Gene associated with autosomal recessive phenotype
  • Strength of Evidence (disclaimer): Gene associated with autosomal recessive phenotype
  • Haploinsufficiency Phenotype: WERNER SYNDROME; WRN

Haploinsufficiency phenotype comments:

Variants in WRN have been reported in individuals with Werner syndrome, an autosomal recessive condition.

  • Triplosensitivity score: 0
  • Strength of Evidence (disclaimer): No evidence for dosage pathogenicity