SOCS5 |
Gene Facts External Data Attribution
- HGNC Symbol
- SOCS5 (HGNC:16852) HGNC Entrez Ensembl OMIM UCSC Uniprot GeneReviews LOVD LSDB ClinVar
- HGNC Name
- suppressor of cytokine signaling 5
- Gene type
- protein-coding gene
- Locus type
- gene with protein product
- Previous symbols
- No previous names found
- Alias symbols
- KIAA0671, SOCS-5, CIS6, CISH6, Cish5
- %HI
- 32.2(Read more about the DECIPHER Haploinsufficiency Index)
- pLI
- 0.54(Read more about gnomAD pLI score)
- LOEUF
- 0.47(Read more about gnomAD LOEUF score)
- Cytoband
- 2p21
- Genomic Coordinates
-
GRCh37/hg19: chr2:46926076-46990268 NCBI Ensembl UCSC GRCh38/hg38: chr2:46698937-46763129 NCBI Ensembl UCSC - MANE Select Transcript
- NM_144949.3 ENST00000394861.3 (Read more about MANE Select)
- Function
- SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5- SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T- helper cell differentiation by inh... (Source: Uniprot)
Dosage Sensitivity Summary (Gene)
Dosage ID:
ISCA-6575
Curation Status:
Awaiting Review
Issue Type:
Dosage Curation -
Gene
Haploinsufficiency:
Awaiting Review
Triplosensitivity:
Awaiting Review
Last Evaluated:
Awaiting Review
Haploinsufficiency (HI) Score Details
Review not yet complete.
Triplosensitivity (TS) Score Details
Review not yet complete.
Genomic View
Select assembly:
(NC_000002.11)
(NC_000002.12)