Gene Facts External Data Attribution

HGNC Symbol
KRAS (HGNC:6407) HGNC Entrez Ensembl OMIM UCSC Uniprot GeneReviews LOVD LSDB ClinVar
HGNC Name
KRAS proto-oncogene, GTPase
Gene type
protein-coding gene
Locus type
gene with protein product
Previous symbols
KRAS2
Alias symbols
KRAS1, K-Ras4B
%HI
0.47(Read more about the DECIPHER Haploinsufficiency Index)
pLI
0(Read more about gnomAD pLI score)
LOEUF
1.24(Read more about gnomAD LOEUF score)
Cytoband
12p12.1
Genomic Coordinates
GRCh37/hg19: chr12:25358180-25403863 NCBI Ensembl UCSC
GRCh38/hg38: chr12:25205246-25250929 NCBI Ensembl UCSC
MANE Select Transcript
NM_004985.5 ENST00000311936.8 (Read more about MANE Select)
MANE Plus Clinical Transcript(s)
NM_033360.4 ENST00000256078.10 (Read more about MANE Plus Clinical)
Function
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:20949621). Plays an important role in the regulation of cell proliferation (PubMed:23698361, PubMed:22711838). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (PubMed:24623306). {ECO:0000269|PubMed:20949621, ECO:0000269|PubMed:22711838, ECO:0000269|PubMed:23698361, ECO:0000269|PubMed:24623306, ECO:0... (Source: Uniprot)

Dosage Sensitivity Summary (Gene)

Dosage ID:
ISCA-7013
Curation Status:
Reopened
Issue Type:
Dosage Curation - Gene
Haploinsufficiency:
Reopened
Triplosensitivity:
Reopened
Last Evaluated:
Reopened

Haploinsufficiency (HI) Score Details

Review not yet complete.

Triplosensitivity (TS) Score Details

Review not yet complete.

Genomic View

Select assembly: (NC_000012.11) (NC_000012.12)