ClinGen Dosage Sensitivity Curation Page

KRAS

  • Curation Status: Complete

Location Information

Select assembly: (NC_000012.11) (NC_000012.12)
  • Haploinsufficiency score: 0
  • Strength of Evidence (disclaimer): No evidence for dosage pathogenicity

Haploinsufficiency phenotype comments:

While deletion/duplication analysis for KRAS is listed in the GeneReviews entry for Noonan syndrome (NS), there have never been any CNVs reported in KRAS that result in NS. Nystr?m et al (PMID: 20302979) investigated a cohort of 44 NS patients for CNVs in PTPN11,SOS1, RAF1, KRAS, BRAF, MEK1, and MEK2 using MLPA. No CNVs in any of the seven genes were identified.

  • Triplosensitivity score: 0
  • Strength of Evidence (disclaimer): No evidence for dosage pathogenicity