Duplication and fusion alleles found in the 3? region of GBA have been mediated by local duplicons (i.e. LCRs). Although, it could not be established whether different mechanisms or sites of recombination result in Gaucher disease, but it could potentially have a modifying effect on phenotype. However no whole gene duplications of GBA have been reported to result in the Gaucher phenotype. see PMIDs: 12587096, 18338393